5 Best Baby Formulas: Know What you Feed Your Baby

More than 54% of babies drink formula exclusively or as a supplement. But finding the right baby formula can often be challenging because not all babies tolerate formula the same. So what worked for one baby might not work for your next. It’s critical to talk to your pediatrician for recommendations for your baby’s particular digestion and needs. That said, we’ll highlight the five best baby formulas on the market. 

Does It Matter What Formula Brand I Give My Baby?

No. There are lots of high-quality baby formulas on the market. So the brand you choose for your baby may not matter as much as the type of formula (such as cow’s milk-based or soy-based) and whether it meets your baby’s nutritional needs. 

Baby formulas sold in the US must meet the same nutritional standards set by the Food and Drug Administration (FDA), which means they are safe for your baby to drink. But it is essential to choose a formula that your baby can tolerate, as some babies may be sensitive or intolerant to certain ingredients. Your pediatrician can help you determine the best formula for your baby’s individual needs.

Can I Switch My Baby from Similac to Enfamil?

Yes, you can switch your baby from Similac to Enfamil or from one brand of formula to another. However, making the switch gradually is essential to give your baby’s digestive system time to adjust. A sudden switch from one formula to another can sometimes cause digestive upset, such as gas, fussiness, or diarrhea.

To make the switch gradually, we recommend the following:

  1. Consult with your pediatrician to identify the best formula for your baby’s needs and guide you in choosing the right brand and type.
  2. Check the ingredients list of the new formula to ensure it will be tolerable for your baby.
  3. Mix small amounts of the new formula with the old formula and gradually increase the new formula over several days.
  4. Watch your baby’s behavior and look for any signs of digestive upset, such as gas, fussiness, or diarrhea. 

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Related Link: Introducing Solids to Baby Guide for Parents


young family feeding their baby with a bottle


The 5 Best Baby Formulas

Here are our best baby formula picks based on popularity, nutrition, and need: 

1. Similac Pro-Advance

Best Overall Baby Formula & Most Recommended by Pediatricians

Similac Pro-Advance is a non-GMO infant formula designed to provide complete nutrition for infants during their first year of life. This is a popular formula because it is gentle on a baby’s digestive system and doesn’t contain genetically modified ingredients (GMOs). 

Similac Pro-Advanced is also one of the best baby formulas for baby brain development because of its nutrient-rich formula.


Pediatricians heavily recommend it because it contains the following:

  • Prebiotics 
  • DHA (Docosahexaenoic Acid)
  • Lutein
  • Vitamin E
  • Other vital vitamins and nutrients


  • Expensive
  • Often out of stock

2. Enfamil Enspire

Best Baby Formula that's Closest to Breast Milk

While it is challenging for baby formula to be identical to breast milk because breast milk is the perfect food for a baby, Enfamil Enspire contains partially hydrolyzed proteins and lactoferrin, which is a protein found in colostrum. It also provides complete infant nutrition, including nutrients supporting brain development. 


  • Emfamil Enspire contains:
  • Lactoferrin
  • DHA 
  • Choline
  • Iron
  • Vitamin E
  • Milk-based
  • Other essential nutrients, such as calcium, phosphorus, and vitamins A, C, and D


  • Only powder form
  • Expensive

3. Enfamil NeuroPro Gentlease

Best Formula for Colic or Gas

Enfamil NeuroPro Gentlease is the best baby formula for babies with colic because it contains partially hydrolyzed proteins, making it easier on sensitive digestive systems. The milk-based formula offers complete nutrition and contains vital ingredients like DHA, HMO, and non-GMO ingredients.


  • Contains partially hydrolyzed proteins, DHA, and HMO
  • Gentle on sensitive stomachs
  • Reduces gas


  • Expensive
  • Can be foamy

123 Babybox utilizes the latest research to craft the best box for your baby’s needs for their stage of development and growth. Learn more about our expertly curated boxes. 

Related Link: What Is Cluster Feeding and Is It Right for My Baby?

4. Earth’s Best Organic Infant Formula

Best Organic Baby Formula

The best organic baby formula on the market is Earth’s Best Organic Infant Formula. It is made with certified organic ingredients, ensuring the formula is free from harmful chemicals and pesticides. 

Made with non-genetically modified ingredients, Earth’s Best Organic Infant Formula provides complete nutrition by blending essential vitamins and minerals needed for healthy growth and development.


  • Contains essential vitamins and minerals
  • Smells better
  • Milk-based
  • DHA
  • ARA
  • More affordable


  • Only available as a powder

5. Kirkland Signature ProCare

Most Affordable Best Baby Formula

We understand that baby formula can be extremely expensive. Kirkland’s Signature ProCare baby formula is a popular generic brand because it contains all the same vitamins and nutrients as the name brands. It is a milk-based formula that contains DHA and lutein, which promote brain and eye development.


  • Most affordable
  • Contains DHA and lutein
  • Kosher and halal certified


  • Only available at Costco
  • It can be foamy and tough on sensitive stomachs


mom bottle feeding her baby


Baby Formula Is Your Best Alternative to Breastmilk

When feeding your baby, we know you want the best for your baby. Whether you’re supplementing with formula or need to exclusively feed your baby formula, you can rest easy knowing that baby formula is a viable, nutrient-rich alternative to breastmilk. 

Consult your pediatrician for the best baby formula for your baby’s needs. They’ll be able to recommend a formula that will be best for your baby and your budget.

At 123 Baby Box, we are committed to helping to boost your baby’s development and growth. We curate a monthly subscription baby box that includes the best developmental toys and products for your baby’s growth stage. 

Related Link: Reheating Breastmilk: What You Need to Know

What to read next

123 Baby Box sources ideas for their blog content from a variety of channels including feedback from subscribers, trending topics in baby care, and insights from industry experts. They aim to cover topics that are both informative and relevant to the needs and interests of parents and caregivers.

The writing process at 123 Baby Box typically involves several steps. First, they outline key points to cover in the article based on thorough research.

123 Baby Box publishes new content on their blog on a weekly basis. This regular schedule helps keep their audience engaged and informed about the latest in baby care, product recommendations, and parenting tips.

The blog posts for 123 Baby Box are typically written by content writers who specialize in parenting, child development, and health. These writers often have backgrounds in journalism, education, or healthcare, providing them with the expertise necessary to produce reliable and valuable content for parents.

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